It is a . We believe this method is very good for measuring concentration and also provides some data on purity. "It very clear that GS-441524 is highly effective against coronavirus infection in cats," he explained. Hero: Hero is a brand that is widely sold in other groups. CUREFIP.COM was found in the summer of 2019, shortly after a friend’s cat was diagnosed with Feline Infectious Peritonitis Virus (FIPV). We will refund you the full value of any unopened/unused vials should our GS prove to be ineffective in treating FIP in your cat. Rusmira started him on GS treatment today as there’s no time to waste! 2018 Jun;219:226-233. Geoffrey Steven Ginsburg. The first question is for your kitties weight, enter that and then select “Lbs” or “Kg” from the dropdown for what system your cat’s weight was measured in. With a clinical efficacy rate of 87%, GS-441524 from CureFip.com is the most effective treatment against wet and dry forms of Feline Infectious Peritonitis (FIP). Please help Silvester fight FiP ️. Kate was among the early members of FIP Warriors, which launched in March as a GS-friendly alternative to FIP Fighters. Distinguished professor Dr. Niels Pederson, legendary researcher at the University of California, Davis has been chasing a solution to FIP for many decades. It appears that FIP has been the hidden disease of cats for a long time, and that with a treatment, we are finally appreciating just how serious it is to our cats. The Nanodrop device is really designed to analyze RNA samples which have a characteristic absorption band in the UV (ultraviolet) which peaks near 260nm (nanometers). Veterinarians, who are under more legal and ethical constraints, may view the black market quite Subsequent, and yet to be published, trials with GS-441524 on 4 cats with severe neurological and/or ocular disease have shown GS to be also effective in these most difficult cases if the drug is given at a high enough dosage. This type of machine is very expensive and more easily damaged. We can see in plot below that the hero data very closely overlays the data for the 15mg/ml Standard. According to a paper published in the journal PLOS ONE, researchers from Kansas State University describe their success with an antiviral treatment for FIP that inhibits the virus from replicating and actually stops the the disease […] The optimum dosage was found to be 4.0 mg/kg SC q24h for at least 12 weeks. Clearly it is not 16.5mg/ml. We can see in plot below that the hero data very closely overlays the data for the 15mg/ml Standard. It typically strikes kittens and young cats under 2 years of age, or older cats whose immune system has been stressed or otherwise compromised. August 6, 2019. What a sad, sorry world we have become if justification for wrongdoing makes you a hero. For those with a high degree of confidence that their cat does have FIP, you can join FIP Warriors. FIP Warriors has grown to more than 2,000 members in five months. FIP tips and startup tutorial; GS Calculator; Reading blood tests While this is a closed group, they welcome anyone who faces FIP and wants to explore the use of the only available source of GS-441524 today.While these drugs are unregulated by any governmental agency, they are proving effective at treating FIP And to be fair, they show the greatest promise. Further, the clinical results should include “tough” cases such as Ocular and neuro forms of FIP. Much higher priority should be given to clinical results of a brand used to treat a large number of cats over the full 84 days of treatment and 84 dyas of post treatment observation. The actual testing was performed by an anonymous contributor at a nearby prestigious university. In order to get GS samples in a good range for measurement, they had to be diluted at 1:120. Since GS is able to bind to RNA in the virus, it turns out that GS has an absorption profile that is similar to RNA in the same range of wavelengths. Pedersen added, “We chose to use GS-441424 for treatment of the coronavirus disease FIP because it had identical antiviral properties to Remdesivir and at the time was not under consideration by Gilead Sciences for use in humans. Cats with neurological FIP may require a progressively higher dosage of 5-10 mg/kg. V závislosti na úrovni buněčné imunity zvířete existuje onemocnění ve dvou formách: GS441524 and GC376 are the two new antiviral drugs responsible for all the recent excitement. Feline infectious peritonitis is a viral disease of cats that is seen worldwide. This mirrors the successes seen in all other regions of the world. GS-441524 proved to be even more potent against FIP and provided hints that even neurological FIP was treatable. Keywords: FIP; GS-441524; Nucleoside analog; feline infectious peritonitis; field trial. While this group does not represent or endorse any GS manufacturer, it can help connect you with different suppliers of GS441524. SAK II GS 441524 (16mg/ml) feline infectious peritonitis(FIP & FIPV), 5.2ml (2-1000 vials) € 59 To determine actual concentration, we prepared Standard samples at various dilutions using GS powder provided by one of the more trusted GS brands. In his most recent study, he successfully treated FIP in 25 of 31 cats using GS-441524. I feel strongly that GS treatment by injection has the highest probability of curing your cat’s FIP and is the only treatment method backed by published research. This sample from a “white cap” bottle is claimed to have a higher GS concentration (than the 15mg/ml standard) of 16.5 mg/ml. As of July 2020, we have completed some useful testing on a number of GS samples. We want to stress that this testing data should not be used as the sole means for selecting a brand. Cats with neurological FIP may require a progressively higher dosage of 5-10 mg/kg. We have helped to save thousands of cats around the world in past 12 months. Infekční peritonitida koček (též felinní infekční peritonitis, anglicky Feline Infectious Peritonitis, odtud běžně používaná zkratka FIP) je závažné infekční virové onemocnění koček způsobené kočičím koronavirem.Postihuje hlavně koťata do dvou let věku a pak staré kočky. The testing includes a mix of current GS brands and some older brands that were suspected of causing problems. This compound is nearly identical Remdesivir. The recommended dosage of GS for cats with non-neurological FIP is 4 mg/kg, SC, once a day, for 12 weeks. The latter group has since revised its policy, and this month began referring pet owners seeking information about the unapproved treatments to FIP Warriors. Feline Infectious Peritonitis, FIP, is caused by a mutation of the typically benign Coronavirus (FCoV). January 20, 2020 Crafting the (near perfect) infomercial August 29, 2019 Worried about your cat’s liver and kidney values? A Nanodrop passes light through a sample and measures the absorption of the light as a function of wavelength (color). ... Mutian GS for FIP, legal or not? Xi'an Holly Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. ... GS-441524 GC-376 and Mutian. Clearly it is not 16.5mg/ml. This sample from a “white cap” bottle is claimed to have a higher GS concentration (than the 15mg/ml standard) of 16.5 mg/ml. A cure for FIP is the holy grail of veterinary medicine. The link below explains more about this disease and why this drug is difficult to get. We will leave the purity discussion for the complete report. Below is a simple calculator for figuring out your GS-441524 dosage for your kitty. This is the what people mean when they caution owners that want to treat their cats that the available products are black market. For several weeks, the FIP community has been waiting for an announcement from Mutian that the company had made good on its promise to have FDA approval for its line of GS pills (called Mutian X), as an OTC drug under the FDA’s GRASE program. This result is of course based on the accuracy of the Standard preparation. The concentrations are quoted relative to 15mg/ml but the actual data shown here was taken at 1:120 dilution. It is a progressive disease that is almost always fatal. Silvester has FiP The poor mite is struggling to breathe with fluid aro... und his lungs and he’s severely anemic. Question two is how many MG per KG of GS should your kitty have each day, in Question three you will select the concentration of you GS. Framber Valdez posted a 26.4% K% over 70.2 IP in 2020, finishing with a 3.57 ERA (2.85 FIP, 2.94 xFIP, 3.23 SIERA) and 22nd in total points among starting pitchers. biotechnology enterprise engaged in the research, development, production and sales of animal . Since an HPLC-MS was not readily available, we have done the best we could with the Nanodrop. Since the Standards were prepared and tested three times, we have high confidence that these results are correct to within 5%. Throughout the course of treatment, remember to weigh your cat frequently and increase his/her dose accordingly with weight gain. Our Guarantee is simple. The higher the peak, the more light was absorbed indicating higher concentration. FIP tips and startup tutorial Moved to FIP Slayer.com. From details of the shape of the curve, we can infer some information about purity. You can choose to become a superhero and save the day, or you can be the bad guy and become a supervillain instead! With advent of COVID-19 on the world scene, people have become more acquainted with corona viruses and the drug Remdesivir – the first cousin to GS-441542 – the cure for FIP. See what these cats owners have to say about us. Eight of the 60 cats survived over 200 days, and 4 of 60 survived over 300 days No historical control cat that suffered solely from dry FIP and not treated with PI lived longer than 200 days. TERMS OF SERVICE   |   PRIVACY POLICY    |    REFUND POLICY, Arrive within 3-5 days to major global destinations in. Wichtige Botschaft von unserem Idol und Schirmherrn Prof. Niels C. P... edersen: I am happy to hear about the success of GS-441524 in Germany. and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. Capella and Brava: The plot below shows three data sets: the 15mg/ml standard, a recent random sample from a Capella shipment, and a recent random sample from a Brava shipment. The surprising result we see here is that the actual concentrations for Capella and Brava are higher than the quoted 15mg/ml. These questions and answers about using GS-441524 come from the FaceBook page FIP Warriors using GS. Eigene anfängliche Studien mit experimentellen FIP zeigten, dass die weniger chemisch Komplex „GS-441524′, die Muttergesellschaft von Nukleosid-GS-5734, war sehr wirkungsvoll, die den Weg für einen Feldversuch bei Katzen mit natürlich vorkommenden FIP. The data suggests that both Capella and Brava are around 18mg/ml and Brava has slightly more GS than Capella. 100% of all proceeds are donated to Zen By Cat to help raise awareness and cure Feline Infectious Peritonitis (FIP). However, a nearly identical compound GS-44124, has worked to treat FIP. Amazing Strange Rope Police – Vice Spider Vegas is a fantastic city simulator game in which you get to control a superhero that is like Spiderman. While RNA has a single absorption band near 260nm, GS has two absorption bands: one near 240nm and another one near 300nm. cats with dry FIP and 59 cats with similar dry FIP from the literature that had not been treated. And I am happy to report that for the first time in history it appears that the grail might be somewhere within reach. Top Purity Gs441524 Injection For Cat,Ocular,Neuro,Wet,Dry Fip/gs 441524//gs-441524 Liquid Cas 1355149-45-9 , Find Complete Details about Top Purity Gs441524 Injection For Cat,Ocular,Neuro,Wet,Dry Fip/gs 441524//gs-441524 Liquid Cas 1355149-45-9,Mutian Mutian Tablets,Pine Injectable//ruby Injectable,Aura Injectable//brava Injectable//hero Injectable from Pharmaceutical … The Nanodrop is an very sensitive instrument. The data discussed here was acquired with an instrument called a Nanodrop Spectrophotometer. Our GS is treatment ready. Common symptoms of the wet form of FIP include: Common symptoms of the dry form of FIP include: Dr. Geoffrey S. Ginsburg's research interests are in the development of novel paradigms for developing and translating genomic information into medical practice and the integration of personalized medicine into health care. This should help take some of the mystery out of what folks are putting in their cats. All that said, if you decide you want to treat with one of the oral forms of GS, I will do my to help you locate a reputable oral form. He says the drug works by blocking the virus’s ability to replicate. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Not all cats infected with the virus causing FIP will become ill, but cats who do develop signs of FIP will likely succumb to the disease eventually. The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and … The gold standard method for purity would be High Pressure Liquid Chromatography with Mass Spectroscopy (HPLC-MS). This group consists mostly of cat parents who have used or who are currently using GS to treat FIP. Data was also acquired at half that dilution (1:60). At this time, we feel that Capella and Brava meet this criteria. Vet Microbiol. They are equally tricky to diagnose. GS Dose Calculator Please contact an FIP Warrior admin for assistance in determining the appropriate starting dose for your cat. Arrive within 3-5 days to major global destinations in Asia, Europe and Middle East. Test Method: There are various possible methods that can be used to test GS samples. Just open the package and begin the treatment. Edgar Maines already mentioned the unavailability of Niels Pedersen's breakthrough drug, which is unlikely to be available within the next five years. The full report and some of what follows is highly technical so if you want to skip all that, you can scroll down where we summarize some of the results. A few years back he approached pharmaceutical company, Gilead Sciences, with a hunch about using its antiviral drug—GS-441524—to combat FIP. There are two forms of the disease: wet form and dry form. Conclusions and relevance: GS-441524 was shown to be a safe and effective treatment for FIP. The recommended dosage of GS for cats with nonneurological FIP is 4 mg/kg, SC, once a day, for 12 weeks. Until now. Professor of Medicine. Thanks for asking. was found in the summer of 2019, shortly after a friend’s cat was diagnosed with Feline Infectious Peritonitis Virus (FIPV). FIP (Feline Infectious Peritonitis) is one of the corona viruses. Veterinarians, who are under more legal and ethical constraints, may view the black market quite differently from owners of cats suffering from FIP. Yet this is what is happening. Feline infectious peritonitis or FIP is probably the number one fatal viral disease of young cats around the world. REFERENCE: 1) Murphy BG, etc. GS-441524 is originally identified as an active metabolite of Remdesivir that is an antiviral drug, a novel nucleotide analog prodrug. Sadly our worst fears have came true! FIP, or Feline Infectious Peritonitis, is a viral disease that affects cats. Hero: Hero is a brand that is widely sold in other groups.